FACTOR-VII COAGULANT ACTIVITY IN RELATION TO SERUM-LIPOPROTEINS AND DIETARY-FAT IN MIDDLE-AGED MEN

The associations of serum lipoproteins and habitual diet to factor VII coagulant activity (FVIIc) were analysed in 119 middle-aged men. FVII c was measured by one-stage clotting assay, cholesterol and triglyceri des enzymatically, serum apolipoproteins (apo) immunoturbidimetrically and habitual diet using four-day food records, ApoB, cholesterol, tri glycerides, apoA-II, LDL cholesterol and dietary fat correlated direct ly to FVIIc (p <0.001). In multivariate analysis apoB, dietary fat and apoA-II explained 35.3% of the variance in FVIIc. In the lowest apoB tertile FVIIc was increased only when fat intake was high (>38 E%), in the middle tertile FVIIc increased gradually from low to high fat int ake, whereas in the highest apoB tertile FVIIc was not related to diet ary fat (p = 0.038 for age-adjusted interaction). The present data dem onstrate a direct relation between apoB and FVIIc in middle-aged men. Low fat diet seem to associate to decreased FVIIc especially in subjec ts in the lower end of the apoB distribution.