REQUIREMENT FOR LIM1 IN HEAD-ORGANIZER FUNCTION

Authors
SHAWLOT W BEHRINGER RR
Citation
W. Shawlot et Rr. Behringer, REQUIREMENT FOR LIM1 IN HEAD-ORGANIZER FUNCTION, Nature, 374(6521), 1995, pp. 425-430
Citations number
50
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Nature → ACNP
ISSN journal
00280836
Volume
374
Issue
6521
Year of publication
1995
Pages
425 - 430
Database
ISI
SICI code
0028-0836(1995)374:6521<425:RFLIHF>2.0.ZU;2-D
Abstract
Lim1 is a homeobox gene expressed in the organizer region of mouse emb ryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embr yos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer.