The internal mammary artery (IMA) is the conduit of choice for cardiac
revascularization. The phenomenon of retrograde flow in this graft se
condary to proximal subclavian artery stenosis is an infrequent but in
creasingly recognized clinical entity and has been termed the ''corona
ry-subclavian steal syndrome.'' We report on five patients with this s
yndrome. All were men. The average age was 65 years (range 56 to 68 ye
ars). The mean interval from coronary bypass to presentation was 7.8 y
ears (range 1 month to 18 years). Three patients presented with unstab
le angina and one with congestive heart failure. One patient was asymp
tomatic from a cardiac standpoint. The mean arm systolic blood pressur
e differential was 45 mm Hg (range 30 to 60 mm Hg). Each patient under
went cardiac catheterization, and retrograde IMA flow was demonstrated
in 100%. Arteriography confirmed the presence of a proximal high-grad
e (>75%) subclavian stenosis in all patients. Stress thallium scanning
was performed in two patients and demonstrated anterolateral ischemia
in both. Operative intervention in four patients consisted of a left
carotid-subclavian bypass using an 8 mm synthetic graft. There was no
perioperative morbidity or mortality. Postoperative thallium scanning
revealed resolution of the ischemic process. The average length of fol
low-up was 20 months (range 12 to 25 months) with all patients remaini
ng asymptomatic. The one patient who refused surgery died at 12 months
. When IMA grafting is contemplated, proximal subclavian stenosis shou
ld be suspected if there is >20 mm Hg systolic pressure differential b
etween the arms. Arch arteriography should then be performed. Likewise
, coronary-subclavian steal syndrome should be suspected in any patien
t with an IMA graft who develops new cardiac symptoms and in whom a br
achial pressure differential is detected. In most cases a carotid-subc
lavian bypass graft provides a safe and durable solution.