A primary method of reducing membrane fouling during cross-flow microf
iltration is periodic reverse filtration. This in situ method of clean
ing the membrane forces clear fluid in the reverse direction through t
he membrane and readjusts the particle or solute accumulation on the r
etentate side of the membrane. This work focuses on the design of a hi
gh-frequency, reverse-filtration strategy to maximize the flux for was
hed yeast suspensions through 0.2-mu m cellulose acetate flat sheet me
mbranes. Several experiments were conducted with reverse-filtration ti
mes ranging from 0.5-4 s and forward-filtration times ranging from 1-4
0 s. For every back-filtration time, there exists an optimum forward-f
iltration time that gives the maximum global average flux. The optimum
average flux increases with decreasing back filtration times and feed
concentrations, but shows little dependence on cross-flow velocity an
d reverse filtration transmembrane pressure. The optimum flux with rap
id backflushing is 20 to 30 times higher than the long-term flux in th
e absence of backflushing. A theory presented assumes that cake format
ion during forward filtration follows dead-end filtration theory and t
he cake is instantly removed during reverse filtration. The measured a
verage flux per cycle follows the trends predicted by the theory, but
the measured values exceed the predictions, presumably due to brief de
lays in cake removal and cake formation at the start of reverse and fo
rward filtration, respectively, during each cycle.