ADJUNCTIVE TREATMENT OF CRANIAL BASE MALIGNANCIES

The indications for skull base tumor surgery have increased in recent years primarily because of improving surgical techniques and adjunctiv e treatment modalities. In this article, we review current and future adjunctive treatment for cranial base malignancies. Surgically clear t umor margins are often difficult to achieve in skull base surgery beca use of unacceptable morbidity to surrounding structures. Current phase I and II trials of adjunctive radiation and chemotherapy are discusse d. Future advances in radiation therapy and chemotherapy are introduce d.