Kd. Daskalakis et al., THE INFLUENCE OF BETA-LACTOGLOBULIN ON THE GROWTH AND DISSOLUTION KINETICS OF HYDROXYAPATITE, Colloids and surfaces. A, Physicochemical and engineering aspects, 96(1-2), 1995, pp. 135-141
The growth rate of hydroxyapatite (HAP) crystallites has been studied
at pH 7.4, using the dual constant composition method. Addition of bet
a-lactoglobulin (beta-Lg) at concentrations greater than about 2 p.p.m
. reduces the growth rate, and the degree of inhibition increases with
additive concentration, up to a value of about 100 p.p.m. Above this
level, however, there is no further decrease in the rate, suggesting a
limiting adsorption of beta-Lg at the HAP surface. beta-Lg also reduc
es the constant composition dissolution rate of HAP, almost completely
inhibiting the reaction after only 25% dissolution at a concentration
of 800 p.p.m. In the absence of the additive the dissolution stops af
ter 60% reaction.