INHIBIN IN NORMAL AND ABNORMAL PREGNANCY - MATERNAL SERUM CONCENTRATION AND PARTIAL CHARACTERIZATION

OBJECTIVE: This study evaluated maternal serum inhibin concentration a nd molecular distribution in normal and abnormal pregnancies. STUDY DE SIGN: Serum inhibin levels were measured by radioimmunoassay in 33 abn ormal pregnancies (23 singleton and 10 multiple gestations) and 33 mat ched controls and were compared with pregnancy variables. RESULTS: In the controls serum inhibin concentrations rose with gestational age (c orrelation coefficient 0.358, p < 0.01) and were higher in mothers wit h female fetuses (p < 0.05). Inhibin levels were higher in the abnorma l singleton pregnancies (2.69 +/- 1.41 ng/ml) than in controls (1.26 /- 0.32 ng/ml, p < 0.0001) and increased more rapidly with gestational age in multiple pregnancies (p < 0.05). Gel filtration chromatographi c analysis of immunoreactive inhibin revealed three peaks with the maj or form having an apparent molecular weight of 55 to 60 kd. CONCLUSION : Maternal serum inhibin concentrations are affected by gestational ag e, fetal gender, and complications of pregnancy. Most of the immunorea ctive inhibin in maternal circulation is a large-molecular-weight form .