Among a series of 6 patients who had paradoxical emboli after pulmonar
y embolus, thrombus was encrusted in the foramen ovale in 2 while cont
rast echocardiography showed a free foramen ovale in the 4 others. Sur
gical embolectomy was performed in 1 of the patients with a thrombus i
n the foramen ovale. This patient died in the post-operative period an
d the second patient died suddenly before the indication for surgery h
ad been established. The 4 other patients were treated medically with
anticoagulant therapy. After a follow-up of 37, 33, 32 and 3 months re
spectively none of these patients has developed recurrent emboli. The
association of a thromboembolic disease and a systemic ischaemic event
should strongly suggest the diagnosis of paradoxical embolus. Echocar
diography is required to determine whether the foramen ovale is free o
r harbours a thrombus.