Sx. Ying et Js. Cheng, EFFECTS OF ELECTROACUPUNCTURE ON C-FOS EXPRESSION IN GERBIL HIPPOCAMPUS DURING TRANSIENT GLOBAL-ISCHEMIA, Acupuncture & electro-therapeutics research, 19(4), 1994, pp. 207-213
We studied the effects of electro-acupuncture (EA) on C-FOS expression
as well as on the histological changes in various regions of hippocam
pus in the gerbil acute global ischemia model. EA was administered at
points of 'Feng-fu' and 'Jin-suo' with a frequency of 7 Hz and an inte
nsity of 6 mA for 30 minutes. EA can substantially potentiate the indu
ction of C-FOS protein like immunoreactivity (CFPLI) in neurons of var
ious regions in hippocampus following transient global ischemia, espec
ially in the CA1 subfield. At the same time EA can prevent most of the
CA1 cells from delayed degeneration after ischemia. These results ind
icate that EA has the protective effect on neurons of hippocampus afte
r cerebral ischemia and C-FOS may be involved in this process.