We evaluated fluorescein angiograms in 174 patients with noninsulin-de
pendent diabetes mellitus. Only one had a skin eruption after ingestin
g fluorescein orally. In 144 patients (83%), the ophthalmoscopic grade
s of diabetic retinopathy were consistent with the fluorescein angiogr
aphic evaluations. In the other 30 patients (17%), differences were no
ted in grading between ophthalmoscopic and fluorescein angiographic fi
ndings. Among the 30 patients, 13 were found by fluorescein angiograph
y to have an area of capillary nonperfusion, which was treated with ph
otocoagulation. According to the fluorescein angiographic findings, 36
patients were treated again with laser photocoagulation, and 44 patie
nts were newly treated. We believe that fluorescein angiography may be
somewhat useful in the management of patients with diabetic retinopat
hy.