DIFFERENTIAL SCANNING CALORIMETRY AS A QUICK SCANNING TECHNIQUE FOR SOLID-STATE STABILITY STUDIES

Authors
VENKATARAM S KHOHLOKWANE M WALLIS SH
Citation
S. Venkataram et al., DIFFERENTIAL SCANNING CALORIMETRY AS A QUICK SCANNING TECHNIQUE FOR SOLID-STATE STABILITY STUDIES, Drug development and industrial pharmacy, 21(7), 1995, pp. 847-855
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
21
Issue
7
Year of publication
1995
Pages
847 - 855
Database
ISI
SICI code
0363-9045(1995)21:7<847:DSCAAQ>2.0.ZU;2-A
Abstract
The potential compatabilities of various commonly used excipients with Indomethacin (IMC) were compared using differential scanning calorime try (DSC). Some agents were found to have no solid state interaction w hereas others showed major changes in the thermograms signifying possi ble interactions in the solid state. The results show that DSC can be employed in preliminary preformulation studies for the evaluation of s olid state interactions as an aid to excipient selection.