FLUIDIZED-BED GRANULATION WITH PVP K90 AND PVP K120

The characteristics and growth mechanisms of fluidized bed granules ar e dependent both on process variables and the grades of PVP binders us ed. Generally, an increase in the concentration, spraying rate and vol ume of binder solution caused an increase in granule size and a decrea se in size distribution. These two factors will in turn affect the pou red and tapped densities of granules. Granules prepared with PVP K90 s olution appeared to grow by primary and secondary agglomeration to giv e an aggregate structure. Granules prepared with PVP K120 solution wer e formed through snowballing as the primary agglomeration process. Thi s occurred at low binder solution concentration with secondary agglome ration taking place when the concentration of PVP K120 solution was in creased.