LIPOSOMES BASED NASAL DELIVERY SYSTEM OF NIFEDIPINE - DEVELOPMENT ANDCHARACTERIZATION

Multilamellar liposomes bearing nifedipine were prepared using a conve ntional cast film method. The prepared liposomes were evaluated for re lease characteristics, in vitro, in situ bioadhesion and in vivo absor ption following nasal administration. Charged components, stearylamine , dicetyl phosphate and some fusogenic/bioadhesive material were also incorporated into the liposomes. It was observed that positively charg ed liposomes possessed maximum bioadhesion while lysophosphatidylcholi ne liposomes showed considerable bioadhesion. In vivo experiments reve aled that the nasal administration of liposomes eliminated hepatic fir st-pass metabolism and could maintain an effective drug concentration for prolonged periods of time with improved bioavailability.