APOPTOTIC AND MITOTIC INDEXES IN MALIGNANT-MELANOMA AND BASAL-CELL CARCINOMA

Aims-To assess the relative frequency of mitotic and apoptotic cells i n malignant melanoma and basal cell carcinoma. Methods-Retrospective e valuation of haematoxylin and eosin stained slides from 10 basal cell carcinomas, 10 nodular melanomas, and 10 superficial spreading melanom as, with counting of apoptotic and mitotic cells per 1000 cells. Selec ted cases were studied with in situ end-labelling. Results-The ratio o f apoptotic to mitotic cells was higher in basal cell carcinoma than i n either form of melanoma because of the presence of a greater number of apoptotic cells in basal cell carcinoma. Conclusion-The differing g rowth rates and biological behaviour of these two tumours is reflected In the apoptotic:mitotic ratio. Further assessment of this ratio is w arranted, both between tumour types and between individual tumours of one type, to determine its value as an indicator of biological potenti al.