DEGENERATIVE CHANGES IN MYOMETRIUM SIMULATING DIFFUSE LEIOMYOMATOSIS AFTER TREATMENT WITH GONADOTROPIN-RELEASING-HORMONE ANALOG

Degenerative changes are encountered relatively frequently in uterine leiomyomas. Morphologic changes within leiomyomas, particularly necros is and alterations in cellularity, have been described following treat ment with gonadotrophin releasing hormone analogue, but the effects of this form of treatment on the morphology of the normal myometrium are less well documented. A case is reported of a 42 year old woman with a history of menorrhagia in whom a combination of degenerative and iat rogenic changes resulted in a histological appearance resembling diffu se leiomyomatosis.