M. Jeffers et al., DEGENERATIVE CHANGES IN MYOMETRIUM SIMULATING DIFFUSE LEIOMYOMATOSIS AFTER TREATMENT WITH GONADOTROPIN-RELEASING-HORMONE ANALOG, Journal of Clinical Pathology, 48(3), 1995, pp. 278-280
Degenerative changes are encountered relatively frequently in uterine
leiomyomas. Morphologic changes within leiomyomas, particularly necros
is and alterations in cellularity, have been described following treat
ment with gonadotrophin releasing hormone analogue, but the effects of
this form of treatment on the morphology of the normal myometrium are
less well documented. A case is reported of a 42 year old woman with
a history of menorrhagia in whom a combination of degenerative and iat
rogenic changes resulted in a histological appearance resembling diffu
se leiomyomatosis.