NEUROPSYCHOLOGY AND NEUROPHYSIOLOGY OF SCHIZOPHRENIA

Distinctive profiles of neuropsychological impairment and neurophysiol ogical abnormalities exist in schizophrenia. At the cognitive level, t hese impairments appear to involve various aspects of working, semanti c, and secondary memory. Some of these deficits may be unresponsive to neuroleptic medication. Functional neuroimaging has indicated a patte rn of cerebral frontal hypoactivity and temporal hyperactivity consist ent with the cognitive findings. Taken together, these results may beg in to account for the frequent and often severe morbidity associated w ith the disorder.