THE RAT-PULL TEST PROCEDURE - A METHOD FOR ASSESSING THE STRENGTH OF RATS

Authors
GIARDINA WJ WISMER CT
Citation
Wj. Giardina et Ct. Wismer, THE RAT-PULL TEST PROCEDURE - A METHOD FOR ASSESSING THE STRENGTH OF RATS, Pharmacology, biochemistry and behavior, 50(4), 1995, pp. 517-519
Citations number
3
Categorie Soggetti
Pharmacology & Pharmacy","Pharmacology & Pharmacy
Journal title
Pharmacology, biochemistry and behavior → ACNP
ISSN journal
00913057
Volume
50
Issue
4
Year of publication
1995
Pages
517 - 519
Database
ISI
SICI code
0091-3057(1995)50:4<517:TRTP-A>2.0.ZU;2-Q
Abstract
A novel method for the measurement of rat strength is described. The m ethod makes use of a rat's natural inclination to move forcibly and ra pidly toward an enclosed, darkened compartment. Acrylamide (200.0 mg/k g, IP), gentamicin (30.0 mg/kg, IP), d-tubocurarine (0.1 mg/kg, IP), a nd diazepam (3.0, 10.0, and 30.0 mg/kg, PO) significantly decreased st rength. The rat-pull test procedure provides a sensitive, reliable, an d valid method for the measurement of strength in rats.