STUDIES ON GROWTH, SPORE-FORMING ABILITY AND VIRULENCE OF THE VACCINESTRAIN TV-M-310 OF THE VACCINE BIOVETA AGAINST RINGWORM

We determined the intensity of growth, the ability to form spores and virulence in guinea pigs of the vaccine strain of the Czech live vacci ne Bioveta. Comparative investigations were carried out with the vacci ne strain of the Russian live vaccine LTF 130 and Trichophyton verruco sum field strains. Growth of the vaccine strains was faster than growt h of the field strains on solid media and in broth. Later the vaccine strains formed many microconidia. In experimentally infected guinea pi gs the virulence of the vaccine strain Bioveta was highly dependent on the infectious dose. At 10(1) CFU ml(-1) (according to the number of CFUs in the Russian live vaccine) the vaccine strain Bioveta was nearl y avirulent. Resuspended according to the manufacturer's instructions (at least 10(10) CFU ml(-1)) virulence of the vaccine strain Bioveta c ould be observed.