ALPHA-THIOTETRONIC ACIDS .1. SYNTHESIS AN D PROPERTIES OF GAMMA-ALKYLIDENE ALPHA-THIOTETRONIC ACIDS

Authors
STACHEL HD ZEITLER K
Citation
Hd. Stachel et K. Zeitler, ALPHA-THIOTETRONIC ACIDS .1. SYNTHESIS AN D PROPERTIES OF GAMMA-ALKYLIDENE ALPHA-THIOTETRONIC ACIDS, Archiv der pharmazie, 328(2), 1995, pp. 99-107
Citations number
31
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
328
Issue
2
Year of publication
1995
Pages
99 - 107
Database
ISI
SICI code
0365-6233(1995)328:2<99:AA.SAD>2.0.ZU;2-V
Abstract
We report on the synthesis of the alkylidene alpha-thiotetronic acids 11 and 12a and a variety of their derivatives, starting with 2,3-dimet hoxysuccinic thioanhydride (4) or diethyl 3-thioxoglutarate. The rhodi um(II) -catalysed decomposition of the diazoketone 26 furnishes the re ductone 12p and the aminoreductone 12r with the thietanone 27 as one o f the by-products.