SYNTHESIS OF PHTHALIMIDO-DESMURAMYLPEPTIDE ANALOGS AS POTENTIAL IMMUNOMODULATING AGENTS

Authors
URLEB U KRBAVCIC A SOLLNER M KIKELJ D PECAR S
Citation
U. Urleb et al., SYNTHESIS OF PHTHALIMIDO-DESMURAMYLPEPTIDE ANALOGS AS POTENTIAL IMMUNOMODULATING AGENTS, Archiv der pharmazie, 328(2), 1995, pp. 113-117
Citations number
28
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
328
Issue
2
Year of publication
1995
Pages
113 - 117
Database
ISI
SICI code
0365-6233(1995)328:2<113:SOPAAP>2.0.ZU;2-3
Abstract
The preparation of immunologically active phthalimido desmuramylpeptid e analogues 2e-h, 4c-d, and 7b is described. The N-acetylmuramic acid in the muramyl dipeptide has been replaced by a phthaloylated acyclic moiety such as N-phthaloylated amino acids 1a-c, 2-(2-phthalimidoethox y)acetic acid 3, or by the carbocyclic rac. trans-2-(2'-phthalimidocyc lohexyloxy)acetic acid 6.