TRANSDERMAL ABSORPTION OF DIMETHINDENE IN MAN

Dimethindene and its metabolite N-demethyldimethindene were determined in human urine after dermal administration of dimethindene. The HPLC- method used was previously described. Data of 8 volunteers are present ed. After 32 h an average of 0.023% of the administered dose of dimeth indene and 0.022% of N-demethyldimethindene were excreted into urine. Since also after oral administration of dimethindene only about 1% of unmetabolised dimethindene is found in urine it can be concluded that a certain amount of dimethindene is absorbed through the skin after de rmal administration.