SOME ANALOGS OF 1,4-DISUBSTITUTED PIPERAZINES AS HYPNOTIC AND SEDATIVE AGENTS

Authors
CHILMONCZYK Z BOGDAL M ZAWORSKA A CYBULSKI J SZELEJEWSKI W
Citation
Z. Chilmonczyk et al., SOME ANALOGS OF 1,4-DISUBSTITUTED PIPERAZINES AS HYPNOTIC AND SEDATIVE AGENTS, Archiv der pharmazie, 328(2), 1995, pp. 187-191
Citations number
20
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
328
Issue
2
Year of publication
1995
Pages
187 - 191
Database
ISI
SICI code
0365-6233(1995)328:2<187:SAO1PA>2.0.ZU;2-4
Abstract
Preparation, analytical data, and biological properties such as acute toxicity, influence on spontaneous and amphetamine induced locomotor a ctivity, hypnotic activity, influence on hexobarbital narcosis and ant iconvulsant activity of new analogues of pyrimidyl piperazines - ethyl 3-[4-(2-pyrimidyl)-1-piperazinyl]-3-oxopropanoate (4), 1-[4-(2-pyrimi dyl)-1-piperazinyl]-1,3-butandione (5), ethyl 3-[4-(2-pyrimidyl)-1-pip erazinyl]butanoate (6) and 4-(2-pyrimidyl)-1-piperazinyl]-2-acetyl-1-h exanone (7) are reported.