PROGNOSTIC VALUE OF PLATELET-FUNCTION DIS TURBANCES IN PATIENTS WITH UNSTABLE ANGINA (RESULTS OF ONE-YEAR FOLLOW-UP)

With the aim of a search for possible platelet related predictors of m yocardial infarction development in unstable angina multifactorial dis criminant analysis of relationship of platelet function characteristic s to results of one year follow-up of 121 patients was performed. Nine teen parameters reflecting various platelet functions - aggregation in vivo and in vitro, lipid composition of and lipid penroxidation in pl atelets were included into analysis. The following 4 parameters had di scriminating power in relation to myocardial infarction development (n =37) and sudden death (n=3) during follow-up: lipid peroxydation produ cts (diene conjugates), tree cholesterol fraction and platelet phoshol ipids - phosphatidyl choline and sphingomyelin. Frequency of correct r etrospective predictions when all these parameters were included into model was 70%, Best coincidence of predicted and observed results of f ollow up (76%) was achieved with the use of 3 parameters - free choles terol, phosphatidyl choline and sphingomyelin in platelets.