SYNTHESIS AND CHARACTERIZATION OF COPPER(II), ZINC(II) AND COBALT(II)COMPLEXES OF SALICYLGLYCINE, A METABOLITE OF ASPIRIN

Copper(II), nickel(II) and cobalt(II) complexes of the aspirin metabol ite salicylglycine (H(2)L), of stoichiometry M(HL)(2) . solvate, have been prepared and characterised. In these complexes salicylglycinate i s coordinated to the metal via its carboxylato group and possibly also its amide oxygen in the copper(II) complex. Under basic conditions co pper(II) forms the complex Cu(LH(-1)). 2H(2)O . MeOH, in which the lig and is coordinated to the metal via its carboxylate and phenolate oxyg en atoms and the deprotonated peptide nitrogen atom.