SNEDDONS SYNDROME IS A THROMBOTIC VASCULOPATHY - NEUROPATHOLOGIC AND NEURORADIOLOGIC EVIDENCE

We report the first case of pathologic findings from brain biopsy in a patient with Sneddon's syndrome. The observations suggest that Sneddo n's syndrome is not a vasculitis but ia more comparable to the autoimm une vasculopathies such as the antiphospholipid antibody syndrome, Vas cular thrombosis and emboli from cardiac sources are the likely causes of stroke in most cases, The success of warfarin in the treatment of antiphospholipid syndromes and the failure of immunosuppression and as pirin in the treatment of Sneddon's syndrome argue that warfarin antic oagulation may be the most appropriate intervention currently availabl e.