LACK OF GENETICALLY-DETERMINED STRUCTURAL VARIANTS OF THE HUMAN SEROTONIN-1E (5-HT1E) RECEPTOR PROTEIN POINTS TO ITS EVOLUTIONARY CONSERVATION

Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-1E (5-HT1E) receptor gene for the pre sence of DNA sequence variation in a sample of 157 unrelated individua ls. We detected only a silent C --> T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT1E receptor protein points to a high evolut ionary conservation of this receptor protein.