CYTOTOXIC CLERODANE DITERPENES FROM POLYALTHIA-BARNESII

Authors
MA X LEE IS CHAI HB ZAW K FARNSWORTH NR SOEJARTO DD CORDELL GA PEZZUTO JM KINGHORN AD
Citation
X. Ma et al., CYTOTOXIC CLERODANE DITERPENES FROM POLYALTHIA-BARNESII, Phytochemistry, 37(6), 1994, pp. 1659-1662
Citations number
26
Categorie Soggetti
Plant Sciences
Journal title
Phytochemistry → ACNP
ISSN journal
00319422
Volume
37
Issue
6
Year of publication
1994
Pages
1659 - 1662
Database
ISI
SICI code
0031-9422(1994)37:6<1659:CCDFP>2.0.ZU;2-F
Abstract
Three cytotoxic clerodane diterpenes were purified from an ethyl aceta te-soluble extract of the stem bark of Polyalthia barnesii, namely, 16 alpha-hydroxyderoda-3,13(14)Z-dien-15,16-olide, a known compound, and two novel compounds, 3 beta,16 ha-dihydroxycleroda-4(18),13(14)Z-dien -15,16-olide and 4 beta,16 alpha-dihydroxyclerod-13(14)Z-en-15,16-olid e. These compounds were found to exhibit broad cytotoxicity against a panel of human cancer cell lines.