ENDOMETRIAL CANCER IN PREMENOPAUSAL WOMEN 45 YEARS AND YOUNGER

Objective: To evaluate the experience with endometrial carcinoma in wo men 45 years or younger at the Royal Hospital for Women, Sydney, Austr alia. Methods: We evaluated the clinical history, morphology, treatmen t, and follow-up of 17 premenopausal women 45 years or younger who had been diagnosed with endometrial cancer. All histopathology was review ed. Results: Sixteen patients received their primary treatment at the Royal Hospital for Women, and one was referred with recurrent disease. Synchronous ovarian malignancies were found in five of 17 cases (29.4 %), compared with 11 of 237 (4.6%) women older than 45 (P < .001). Thr ee other patients had secondary ovarian involvement. Five (29%) patien ts had stage III or IV disease. Thirteen (76.5%) women were alive with no evidence of disease 12-78 months after primary surgery; two were l ost to follow-up, but had no evidence of disease at 21 and 29 months, respectively. Two women died of recurrent disease. All but two patient s with stage IV disease receiving primary treatment at the Royal Hospi tal for Women were offered hormone replacement therapy on discharge fr om the hospital. Conclusion: Ovarian and lymph node involvement were c ommon in women 45 years and younger with endometrial cancer. Hormone r eplacement therapy did not appear to compromise survival.