RANDOMIZED STUDY OF PREINDUCTION CERVICAL RIPENING WITH SEQUENTIAL USE OF INTRAVAGINAL PROSTAGLANDIN E(2) GEL

Objective: To evaluate the safety and efficacy of serial frequent intr avaginal prostaglandin (PG) E(2) gel applications in shortening the ti me required to achieve an inducible cervix. Methods: From May 1, 1993, through April 30, 1994, 101 pregnant women with medical indications f or induction of labor and Bishop scores less than 7 were randomized to receive intravaginal 2.5 mg of PGE(2) gel every 6 hours or as often a s every hour until the Bishop score was at least 7 or intervention was required. Results: The mean total number of PGE, gel applications was significantly different between the 1- and 6-hour groups, 6.5 and 4.4 PGE(2) applications, respectively. The mean time from PGE(2) applicat ion to delivery was similar, 42 and 45 hours, for the 1- and 6-hour gr oups, respectively. The intervention rate, occurrence of labor during ripening, and neonatal outcomes were also similar. Conclusion: Intrava ginal application of 2.5 mg PGE(2) gel as frequently as every hour app ears to be safe, but it does not decrease the time interval to inducti on or delivery, nor does it decrease the cesarean rate.