F. Rodriguezpanadero et al., FAILURE OF TALC PLEURODESIS IS ASSOCIATED WITH INCREASED PLEURAL FIBRINOLYSIS, American journal of respiratory and critical care medicine, 151(3), 1995, pp. 785-790
Citations number
24
Categorie Soggetti
Emergency Medicine & Critical Care","Respiratory System
Diffuse pleural inflammation and fibrin deposition following the insti
llation of the sclerosing agent is considered necessary for a successf
ul pleural symphysis. We hypothesized that an impairment in fibrin for
mation or an increased endopleural fibrinolysis would lead to failure
of pleurodesis. To investigate changes in the pleural coagulation/fibr
inolysis balance, we studied 75 consecutive patients who underwent tho
racoscopy. Fifty-four of these patients with malignant pleural effusio
ns and four with a benign recurrent effusion underwent thoracoscopic t
alc pleurodesis. Another four patients with malignancy and 13 with ben
ign effusions had no talc poudrage performed and were included as a co
ntrol group. Serial determinations of thrombin-antithrombin III comple
x (TAT), plasminogen activator inhibitor (PAI), and D-dimer were made
in pleural fluid samples taken at the beginning of thoracoscopy (basel
ine), immediately after thoracoscopic biopsies had been done (postbiop
sy), 3 h after thoracoscopy-either with; talc poudrage or without-and
24 and 48 h after the procedure, as well as in cases of recurrence of
effusions (farline). Successful pleurodesis was obtained in 42 of 52 p
atients who could be evaluated (81%), and failure was seen in 10. Stro
ng activation of coagulation and production of PAI was observed in all
groups, including the control (no talc) group. Fibrinolytic activity
(as expressed by D-dimer levels) showed a clear decline 24 h after tal
c poudrage in patients with a good outcome of pleurodesis, as opposed
to those with bad results and to the control group, and returned to th
e baseline by 15 d. We conclude that increased pleural fibrinolytic ac
tivity is associated with failure of pleurodesis, despite significant
inhibitory activity of PAI in all groups.