SYNTHESIS OF POTENTIAL CYTOCHROME P450(11-BETA)-GENERATED INTERMEDIATES

Authors
COUSTAL S FAGART J DAVIOUD E MARQUET A
Citation
S. Coustal et al., SYNTHESIS OF POTENTIAL CYTOCHROME P450(11-BETA)-GENERATED INTERMEDIATES, Tetrahedron, 51(12), 1995, pp. 3559-3570
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
12
Year of publication
1995
Pages
3559 - 3570
Database
ISI
SICI code
0040-4020(1995)51:12<3559:SOPCPI>2.0.ZU;2-L
Abstract
Cytochrome P-450(11 beta) is a key enzyme in the biosynthesis of aldos terone which catalyzes the transformation of 11--deoxycorticosterone ( DOC) to aldosterone via three successive hydroxylations (at C-11 and a t C-18). This enzyme is irreversibly inactivated by 18-VP 1 and 18-EP 4. In order to determine the mechanism of the inactivation, we have sy nthesized three potential reactive enzyme-generated intermediates 2, 3 and 5.