DISACCHARIDES AS ENDOMANNOSIDASE INHIBITORS - SYNTHESES OF ALPHA-HOMOMANNOJIRIMYCIN AND BETA-HOMOMONANNORIMYCIN LINKED TO D-GLUCOSE AND D-MANNOSE

Authors
SUHARA Y ACHIWA K
Citation
Y. Suhara et K. Achiwa, DISACCHARIDES AS ENDOMANNOSIDASE INHIBITORS - SYNTHESES OF ALPHA-HOMOMANNOJIRIMYCIN AND BETA-HOMOMONANNORIMYCIN LINKED TO D-GLUCOSE AND D-MANNOSE, Chemical and Pharmaceutical Bulletin, 43(3), 1995, pp. 414-420
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
3
Year of publication
1995
Pages
414 - 420
Database
ISI
SICI code
0009-2363(1995)43:3<414:DAEI-S>2.0.ZU;2-T
Abstract
4-O-(alpha-D-Glucopyranosyl)-alpha HMJ (Glc alpha 1,4HMJ), 4-O-(alpha- mannopyranosyl)-alpha HMJ (Man alpha 1,4 alpha HMJ), 4-O-(alpha-glucop yranosyl)-beta HMJ (Glc alpha 1,4 beta HMJ), and 4-O-(alpha-mannopyran osyl)-beta HMJ (Man alpha 1, 4 beta HMJ) were synthesized as endomanno sidase inhibitors which are potentially useful both for probing the pa thways of N-linked glycoprotein processing and for the chemotherapy of some viral diseases.