T. Makino et al., EFFECT OF STARCH PASTE PREPARATION TEMPERATURE IN FLUIDIZED-BED GRANULATION ON RESULTANT TABLET PROPERTIES, Chemical and Pharmaceutical Bulletin, 43(3), 1995, pp. 473-475
An Onlator(R), a heat exchanger, was utilized as a continuous starch p
aste supplier for a fluidized-bed granulator. Ascorbic acid was used a
s a model drug substance and cornstarch as the binder. To control the
temperature of cooking starch paste, modes of proportional control (P
control) and proportional integral deviation (PID control) were used t
o distinguish their respective effects on the tablet properties. It wa
s shown that the PID control caused less variation in the temperature
of cooking starch paste and, in accordance with this, that variation i
n disintegration time for the resultant tablets was less. There was, h
owever, little difference in tablet hardness between these two modes o
f control.