E. Horisawa et al., EFFECT OF BINDER CHARACTERISTICS ON THE STRENGTH OF AGGLOMERATES PREPARED BY THE WET-METHOD-II, Chemical and Pharmaceutical Bulletin, 43(3), 1995, pp. 488-492
The effect of the physicochemical properties of binders on the strengt
h of granules prepared by the wet method was investigated using hydrop
hobic and hydrophilic powders with various polymer binders, A crushing
test of granules and the amount of fine granules generated during a s
ieving test were carried out in order to estimate the strength of the
granules. In all the powder/binder systems, the surface polarities of
both powders and binders, as well as the degree of polymerization of a
binder, are important factors in determining the strength of granules
, That is, binders and powders whose polarities are similar are capabl
e of producing strong granules. In some systems, the strength of granu
les increased with the degree of polymerization of the polymer binders
.