EFFECT OF BINDER CHARACTERISTICS ON THE STRENGTH OF AGGLOMERATES PREPARED BY THE WET-METHOD-II

Citation
E. Horisawa et al., EFFECT OF BINDER CHARACTERISTICS ON THE STRENGTH OF AGGLOMERATES PREPARED BY THE WET-METHOD-II, Chemical and Pharmaceutical Bulletin, 43(3), 1995, pp. 488-492
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
ISSN journal
00092363
Volume
43
Issue
3
Year of publication
1995
Pages
488 - 492
Database
ISI
SICI code
0009-2363(1995)43:3<488:EOBCOT>2.0.ZU;2-S
Abstract
The effect of the physicochemical properties of binders on the strengt h of granules prepared by the wet method was investigated using hydrop hobic and hydrophilic powders with various polymer binders, A crushing test of granules and the amount of fine granules generated during a s ieving test were carried out in order to estimate the strength of the granules. In all the powder/binder systems, the surface polarities of both powders and binders, as well as the degree of polymerization of a binder, are important factors in determining the strength of granules , That is, binders and powders whose polarities are similar are capabl e of producing strong granules. In some systems, the strength of granu les increased with the degree of polymerization of the polymer binders .