ANALYSIS OF MONOCLONAL IMMUNOGLOBULIN LIGHT-CHAINS IN URINE USING 2-DIMENSIONAL ELECTROPHORESIS

High-resolution two-dimensional electrophoresis was used to analyze ka ppa-type monoclonal immunoglobulin light chains in urine of two patien ts with multiple myeloma. The patients were treated, remission lasted about 2.5 years. In the period of relapse of the disease, acid isoform s of kappa chains, pI < 4,95, which had not been present in the urine of these patients before, were found in urine of both patients. Kappa- type Bence-Jones protein in urine of one patient showed unusual behavi or: It failed to precipitate in the range of 40-60 degrees C or on boi ling.