TOXICITY OF TOXAPHENE ON THE LIPID PROFILE IN THE VITAL ORGANS OF GUINEA-PIG, CAVIA-PROCELLUS

The impact of acute and subacute toxicity of toxaphene on the lipid pr ofile was studied in the vital organs to evaluate certain subtle chang es. Brain and liver revealed significant reduction in the phospholipid content with a definite increase in neutral lipid in brain and liver and cholesterol in brain. No appreciable changes were noticed in the l ipid components in kidney excepting a significant reduction in the pho spholipid content. Regarding phosphoglycerides, brain, liver and kidne y revealed an increase in phosphatidyl inositol and phosphatidic acid associated with a marginal decrease in phosphatidyl ethanolamine, phos phatidyl serine and cardiolipin. Sphingomyelin revealed a significant. increase in brain with a concomittant insignificant decrease of phosp hatidyl choline and vice versa in liver and kidney. Liver accumulated more amount of toxaphene than kidney during subacute treatment.