The results of a prospective assessment of cardiorespiratory changes r
elated to anaesthesia and laparoscopic Nissen fundoplication are descr
ibed in 25 children aged 1.2 to 14.3 years, weighing 9.0 to 64.0 kg. R
espiratory disease or oesophagitis were present in 68% cases. During b
alanced inhalational anaesthesia, hypotension or bradycardia occurred
prior to peritoneal insufflation in three cases of reverse Trendelenbu
rg position. During surgery, intra-abdominal pressure was in the 6-10
mmHg range. Transiently, two patients were hypotensive while ten were
hypertensive. PETCO(2) gradually increased but only two patients requi
red increased minute ventilation. One bronchial intubation episode dev
eloped. Airway complications were related to isoflurane administration
. Postoperatively, transient hypoxia (25% cases) was observed during t
he first 3 h. Analgesia duration was in the 40-1440 min range. Hospita
l stay was 5.6 +/- 1.5 days (mean +/- SD). Laparoscopic paediatric fun
doplication is safe when hypovolaemia and postoperative hypoxia are pr
evented.