CHANGES IN IL-6 AND IL-8 AFTER HEPATECTOMY IN PATIENTS WITH LIVER-CIRRHOSIS

Changes in tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) were inve stigated before and after hepatectomy in patients with or without live r cirrhosis (5 cases without liver cirrhosis and 14 cases with liver c irrhosis). Both the IL-6 and IL-8 values of the cirrhotic patients wer e significantly higher on the first postoperative day (POD) as compare d with the non-cirrhotic patients. Overall, no significant correlation was found between peak values of IL-6 or IL-8 and blood loss or opera ting time. In the case of the cirrhotic patients, correlation of both IL-6 and IL-8 with operating time was significant at p<0.05, gamma=0.5 34 and 0.586, respectively. No correlation was found between blood los s and the peak value of IL-6, but significant correlation (gamma=0.647 , p<0.05) was found between them in cirrhotic patients. There was no c onsistent increase in TNF-alpha and IL-1 beta following hepatectomy. T hese findings indicate that procedures undertaken to reduce the excess ive production of these cytokines may be useful for preventing complic ations after hepatectomy in cirrhotic patients.