PC PROGRAM FOR DETERMINING THE DOSE NECESSARY TO PRODUCE A GIVEN AMOUNT OF CHANGE

Given a simple linear regression equation of the form D = alpha + beta Z, it is well-known how to predict, and construct confidence interval s for, the value of D corresponding to a given Z. In this paper we des cribe, illustrate and make available a menu-driven PC program which ca n be used to solve the inverse problem, namely, to estimate and constr uct confidence intervals for the value of Z corresponding to a given v alue of D. We describe the procedure in the context of a dose-response relationship, where it is desired to estimate the dose (Z) to effect a given amount of change (D), but the method is more general than this . In particular, it may be usefully applied in calibration problems wh ere one may wish to estimate the true value of a measurement given the value as read from a measuring device.