THE RADIATION-CHEMISTRY OF D(CPGPTPA) IN THE PRESENCE OF OXYGEN

Authors
BUDZINSKI EE DAWIDZIK JD WALLACE JC FREUND HG BOX HC
Citation
Ee. Budzinski et al., THE RADIATION-CHEMISTRY OF D(CPGPTPA) IN THE PRESENCE OF OXYGEN, Radiation research, 142(1), 1995, pp. 107-109
Citations number
7
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Radiation research → ACNP
ISSN journal
00337587
Volume
142
Issue
1
Year of publication
1995
Pages
107 - 109
Database
ISI
SICI code
0033-7587(1995)142:1<107:TRODIT>2.0.ZU;2-S
Abstract
This report extends our investigation of double base lesions produced by irradiation of DNA model compounds. Studies of d(CpGpTpA) X-irradia ted in oxygenated aqueous solution show that two of the five principal products are oligomers having adjacent bases damaged. In these oligom ers guanine is hydroxylated at the 8-position and an adjacent pyrimidi ne is degraded to a formamido remnant. (C) 1995 by Radiation Research Society