Ka. Nathavitharana et al., PRESENCE OF SECRETORY IGA ANTIBODIES TO AN ENTERIC BACTERIAL PATHOGENIN HUMAN-MILK AND SALIVA, Archives of Disease in Childhood, 72(2), 1995, pp. 102-106
The concept of a common mucosal immune system in man was tested by exa
mining the concurrent presence of specific-secretory IgA (SIgA) antibo
dies in human milk and saliva from three groups of subjects: 64 Sri La
nkan women living in Sri Lanka; 20 immigrant Asian women Living in Bir
mingham (median duration of residence in the United Kingdom five years
); and 75 Caucasian women Living in Birmingham (controls). Enzyme Link
ed immunosorbent assays (ELISA) were developed to detect enterotoxigen
ic Escherichia coli (ETEC) colonisation factor/1 (CFA/1) specific SIgA
antibodies in milk and saliva. ETEC CFA/1 specific SIgA antibody acti
vity was detectable in milk (37.5% and 25%) and saliva (42.1% and 35%)
of Sri Lankan and immigrant Asian women, respectively, but not in any
of the Caucasian controls. Eighty five point two per cent of subjects
who were positive had specific antibodies detectable in both milk and
saliva; 5% of all Sri Lankan women and 10% of all immigrant Asian wom
en had detectable antibody only in saliva. These observations lend fur
ther strong support to the idea that a common mucosal immune system ex
ists in man. The continuing presence of specific SIgA antibodies in As
ian immigrants to previously encountered antigens suggests that there
may be an 'immunological memory' in the human secretory immune system.