HIGH-INCIDENCE OF CONSERVATIVE RAS MUTATIONS IN ACUTE MYELOID-LEUKEMIA

Citation
I. Aurer et al., HIGH-INCIDENCE OF CONSERVATIVE RAS MUTATIONS IN ACUTE MYELOID-LEUKEMIA, Acta haematologica, 92(3), 1994, pp. 123-125
Citations number
24
Categorie Soggetti
Hematology
Journal title
ISSN journal
00015792
Volume
92
Issue
3
Year of publication
1994
Pages
123 - 125
Database
ISI
SICI code
0001-5792(1994)92:3<123:HOCRMI>2.0.ZU;2-W
Abstract
RAS mutations are found in about 25% of acute myeloid leukemia (AML) c ases. The importance of these changes is unknown, If RAS mutations con fer growth advantage to leukemia subclones in which they emerge, subst antially more nonconservative than conservative mutations should be fo und. The incidence of conservative mutations was not reported previous ly. We sequenced N-RAS and K-RAS codons 12 and 13 and N-RAS codon 61 i n 20 subjects with newly diagnosed AML. Four nonconservative N-RAS mut ations and 4 conservative K-RAS mutations were found. There were no di fferences between subjects with AML and nonconservative RAS mutations and those with conservative or without RAS mutations, Additional. stud ies are needed to examine the incidence of conservative RAS mutations in subjects with AML.