EXACT ANALYSIS FOR PAIRED BINARY DATA

This paper provides an efficient algorithm to generate exact distribut ions for the bivariate logistic model with common and sub-unit-specifi c covariates. The algorithm can be used to analyze correlated paired b inary response data from studies lacking a large sample size. Possible applications include a clinical trial with two distinct binary outcom es, a binary outcome cross-over or two-time point cohort study, and a pair-matched prospective study with binary outcome. Analysis of data f rom an ophthalmologic study is provided to illustrate the method. Exte nsion to three or more correlated binary responses is also outlined.