HYBRIDIZATION PROPERTIES OF THE 5-METHYL-ISOCYTIDINE ISOGUANOSINE BASE-PAIR IN SYNTHETIC OLIGODEOXYNUCLEOTIDES

Authors
HORN T CHANG CA COLLINS ML
Citation
T. Horn et al., HYBRIDIZATION PROPERTIES OF THE 5-METHYL-ISOCYTIDINE ISOGUANOSINE BASE-PAIR IN SYNTHETIC OLIGODEOXYNUCLEOTIDES, Tetrahedron letters, 36(12), 1995, pp. 2033-2036
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
12
Year of publication
1995
Pages
2033 - 2036
Database
ISI
SICI code
0040-4039(1995)36:12<2033:HPOT5I>2.0.ZU;2-8
Abstract
The hybridization properties of the 5-methyl-isocytidine / isoguanosin e base pair in synthetic oligodeoxynucleotides have been investigated. The 5-methyl isocytidine / isoguanosine base pair has been determined to be isoenergetic with the cytidine / guanosine, and each base can e ffectively discriminate mismatches. The synthesis of oligodeoxynucleot ides containing 5-methyl-2'-deoxyisocytidine was improved using N-2-(( di-n-butylamino)methylene) protection.