STUDIES ON TRIFLUOROMETHYLPHOSPHONAMIDITE ANALOGS AS BUILDING-BLOCKS IN OLIGONUCLEOTIDE SYNTHESIS

Authors
MAYER M UGI I RICHTER W
Citation
M. Mayer et al., STUDIES ON TRIFLUOROMETHYLPHOSPHONAMIDITE ANALOGS AS BUILDING-BLOCKS IN OLIGONUCLEOTIDE SYNTHESIS, Tetrahedron letters, 36(12), 1995, pp. 2047-2050
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
12
Year of publication
1995
Pages
2047 - 2050
Database
ISI
SICI code
0040-4039(1995)36:12<2047:SOTAAB>2.0.ZU;2-O
Abstract
The phosphorylating reagents CF3P(NMe(2))Cl and CF3P(NEt(2))Cl are use d to phosphorylate the 3'-hydroxyl moiety of several protected 2'-deox ynucleosides yielding the corresponding nucleoside trifluoromethyl pho sphonamidites. Their scope and limitations towards amidite activation are investigated but, however, their behavior is completely different to commonly used nucleoside phosphorus amidites.