DIHYDROQUINIDINE CONFORMATION REVISITED - VARIABLE-TEMPERATURE NMR AND CD SPECTROSCOPY, AND MOLECULAR MECHANICS COMPUTATIONS

Authors
BERG U AUNE M MATSSON O
Citation
U. Berg et al., DIHYDROQUINIDINE CONFORMATION REVISITED - VARIABLE-TEMPERATURE NMR AND CD SPECTROSCOPY, AND MOLECULAR MECHANICS COMPUTATIONS, Tetrahedron letters, 36(12), 1995, pp. 2137-2140
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
12
Year of publication
1995
Pages
2137 - 2140
Database
ISI
SICI code
0040-4039(1995)36:12<2137:DCR-VN>2.0.ZU;2-I
Abstract
Combination of variable temperature NMR and CD spectroscopy, and molec ular mechanics computations shows that dihydroquinidine exists in two conformations, anti,open (80-90%) and syn,closed (10-20%) separated by a barrier of 8.3 kcal/mol in ether solutions.