N-[BIS(METHYLTHIO)METHYLENE]AMINO ESTERS (BMMA) - NOVEL REAGENTS FOR ANNELATION OF PYRIMIDINE MOIETIES

Authors
SAUTER F FROHLICH J BLASL K GEWALD K
Citation
F. Sauter et al., N-[BIS(METHYLTHIO)METHYLENE]AMINO ESTERS (BMMA) - NOVEL REAGENTS FOR ANNELATION OF PYRIMIDINE MOIETIES, Heterocycles, 40(2), 1995, pp. 851-866
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
40
Issue
2
Year of publication
1995
Pages
851 - 866
Database
ISI
SICI code
0385-5414(1995)40:2<851:NE(-NR>2.0.ZU;2-B
Abstract
New reagents for heterocyclic annelations containing a N-[bis(methylth io)methylene]amino moiety (=BMMA) were developed and studied regarding their scope and limitations: one-pot reaction with (hetero)aromatic o rtho-aminocarbonyl-type model compounds (''carbonyl'' = COOEt, COMe an d CN) to a series of new benzo- or thieno-condensed pyrimidines, pyrro lo[1,2-c]pyrimidines, imidazo[1,2-c]pyrimidines and 1,2,4-triazolo[1,5 -c]pyrimidines, depending on the reagent used [(MeS)(2)C=N-R with R = CH2-COOEt, CH(2)CH(2)COOEt, NH-COOEt].