COMPARISON OF FLUID VOLUMES WITH WHOLE BOWEL IRRIGATION IN A SIMULATED OVERDOSE OF IBUPROFEN

OBJECTIVE: To determine the effect of 2 different fluid volumes of pol yethylene glycol whole bowel irrigation (WBI) solution on absorption o f an ingested toxin in a simulated overdose model. DESIGN: Prospective , randomized, crossover trial. SETTING: Clinical research unit. PARTIC IPANTS: Nine adult men. INTERVENTIONS: On 2 separate days, volunteers ingested approximately 75 mg/kg of ibuprofen. In treatment 1, 30 minut es after ingestion of ibuprofen, a 3-L WBI at 2 L/h was begun. This pr ocedure was repeated in treatment 2 with an 8-L WBI administered at 2 L/h. Fourteen timed serum samples were collected prior to and after dr ug ingestion for a 24-hour period and analyzed for ibuprofen concentra tion. The peak serum concentration, time to peak concentration, total area under the serum concentration-time curve (AUG), clearance, and vo lume of distribution were compared. RESULTS: The mean +/- SD AUCs did not differ between the 3-L (1185.3 +/- 216.9 mg.h/L) and 8-L (1153.5 /- 251.5 mg.h/L) treatments (p = 0.710). Time to peak serum concentrat ion, peak serum concentration, clearance, and volume of distribution w ere comparable for the 2 treatments (p > 0.05). CONCLUSIONS: These dat a indicated that a total WBI volume of 3 L would be expected to perfor m as well as 8 L administered at the same rate. We recommend that furt her research define the optimal dose of WBI in acute ingestion of toxi ns.