INHIBITORY EFFECTS OF STEROIDAL SAPONINS ON 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA)-ENHANCED P-32 INCORPORATION INTO PHOSPHOLIPIDS OF HELA-CELLS AND PROLIFERATION OF HUMAN-MALIGNANT TUMOR-CELLS

Authors
MIMAKI Y SASHIDA Y KURODA M NISHINO A SATOMI Y NISHINO H
Citation
Y. Mimaki et al., INHIBITORY EFFECTS OF STEROIDAL SAPONINS ON 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA)-ENHANCED P-32 INCORPORATION INTO PHOSPHOLIPIDS OF HELA-CELLS AND PROLIFERATION OF HUMAN-MALIGNANT TUMOR-CELLS, Biological & pharmaceutical bulletin, 18(3), 1995, pp. 467-469
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
18
Issue
3
Year of publication
1995
Pages
467 - 469
Database
ISI
SICI code
0918-6158(1995)18:3<467:IEOSSO>2.0.ZU;2-F
Abstract
Certain Lilium plants contain (25S)-spirost-5-ene-3 beta,27-diol glyco sides embracing 3-hydroxy-3-methylglutaric acid at the C-27 hydroxy po sition. One of their derivatives, methyl ester of O-[(S)-3-hydroxy-3-m ethylglutaryl]-spirost-5-ene-3 beta,27-diol -D-glucopyranosyl-(1-->4)] -beta-D-glucopyranoside} was found to inhibit 12-O-tetradecanoylphorbo l-13-acetate (TPA)-stimulated P-32-incorporation into the phospholipid s of human cervical cancer (HeLa) cells and also to inhibit the prolif eration of various kinds of human malignant tumor cells, pancreatic ca ncer (PANC-1), osteosarcoma (OST), human gastric cancer (HGC-27), pheo chromocytoma (PC-12) and HeLa cells, in vitro.