STABILITY, SPECIFIC BINDING-ACTIVITY, AND PLASMA-CONCENTRATION IN MICE OF AN OLIGODEOXYNUCLEOTIDE MODIFIED AT 5'-TERMINAL WITH POLY(ETHYLENE GLYCOL)

Authors
KAWAGUCHI T ASAKAWA H TASHIRO Y JUNI K SUEISHI T
Citation
T. Kawaguchi et al., STABILITY, SPECIFIC BINDING-ACTIVITY, AND PLASMA-CONCENTRATION IN MICE OF AN OLIGODEOXYNUCLEOTIDE MODIFIED AT 5'-TERMINAL WITH POLY(ETHYLENE GLYCOL), Biological & pharmaceutical bulletin, 18(3), 1995, pp. 474-476
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
18
Issue
3
Year of publication
1995
Pages
474 - 476
Database
ISI
SICI code
0918-6158(1995)18:3<474:SSBAPI>2.0.ZU;2-E
Abstract
Oligodeoxynucleotide (ODN) composed of 15 nucleotides was modified at 5'-terminal phosphate with hexylamine linker and chemically activated poly(ethylene glycol). This derivative showed improved characteristics in terms of enzymatic stability, binding activity, and in vivo retent ion in mouse. The data are discussed in comparison with those of corre sponding unmodified and phosphorothioate ODNs.